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KMID : 1201420160090020174
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Journal of Neurocritical Care
2016 Volume.9 No. 2 p.174 ~ p.177
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A Case of Leuprolide-Induced Posterior Reversible Encephalopathy Syndrome
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Lee Chae-Young
Hwang Sung-Hee
Hong Seong-Sook
Jung San
Minn Yang-Ki
Kwon Seok-Beom
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Abstract
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Background: Leuprolide is a gonadotropin releasing hormone agonist used for patients with prostate cancer and a variety of gynecologic diseases, such as uterine myoma, endometriosis, and adenomyosis. Reported side effects include a local skin eruptions, anaphylactoid reactions, ischemic heart diseases, and seizures.
Case Report: A 41-year-old woman showed the sudden onset of headache. She had a history of being treated by leuprolide for adenomyosis. Her vital sign was stable. Laboratory findings were within a normal range. Right homonymous quadrantanoptic scotoma was observed on perimetry. Her brain magnetic resonance imaging (MRI) showed high signal lesions on T2-weighted (T2WI) and fluid attenuated inversion recovery images affecting left occipital cortex. The MRI results were compatible with the features of posterior reversible encephalopathy syndrome (PRES).
Conclusion: To the best of our knowledge, this is the first case to report a possible association between PRES and the usage of leuprolide.
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KEYWORD
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Leuprolide, Posterior reversible encephalopathy syndrome, Brain magnetic resonance imaging
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